Question 1
5 of 15. A 12-year-old boy is brought to urgent care exhibiting audible wheezing and accessory muscle use. He is speaking in short, fragmented phrases and his SpO2 is 90% on room air. Which initial pharmacotherapeutic intervention is most appropriate?
- A) Administer nebulized albuterol alongside a systemic oral corticosteroid dose.
- B) Administer combined albuterol and ipratropium alongside oral corticosteroid therapy.✓
- C) Administer nebulized albuterol alongside an intravenous magnesium sulfate infusion.
- D) Administer combined albuterol and ipratropium alongside intravenous magnesium therapy.
💡 Key Takeaway
Severe asthma exacerbations require combination therapy with a SABA, a SAMA, and systemic corticosteroids.
Show rationale
The patient's accessory muscle use and inability to speak in full sentences indicate a severe asthma exacerbation. Current guidelines recommend the immediate use of a short-acting beta-agonist combined with a short-acting muscarinic antagonist, such as albuterol and ipratropium, along with systemic corticosteroids to maximize bronchodilation and reduce inflammation. Using albuterol alone is sufficient for mild-to-moderate exacerbations but suboptimal for severe cases. Intravenous magnesium sulfate is reserved for life-threatening exacerbations or those that remain unresponsive to initial intensive bronchodilator therapy; it is not the first-line step before administering systemic steroids.