Question 1
22 of 150. A patient with frequent dysphagia asks the medical assistant if they can crush their enteric-coated aspirin before swallowing. Recognizing absorption principles, what is the most accurate response?
โธ Why D is the answer
Enteric-coated medications are designed to resist the acidic environment of the stomach and dissolve only once they reach the more alkaline small intestine. Option D is correct because crushing the pill destroys this protective layer, causing premature release in the stomach, which can lead to severe gastric irritation or drug degradation. Option A is incorrect because crushing would actually speed up absorption, not delay it, albeit in the wrong location. Option B is incorrect because the first-pass effect occurs after absorption into the portal vein, regardless of whether the pill is crushed. Option C is incorrect because crushing affects the absorption phase, not the systemic distribution or spread of the active drug.
๐ Key takeaway
Enteric coatings protect medications from stomach acid and prevent gastric irritation until reaching the intestines.